Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase

R N Atkinson; S B King

doi:10.1016/s0960-894x(99)00509-0

Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase

Bioorg Med Chem Lett. 1999 Oct 18;9(20):2953-8. doi: 10.1016/s0960-894x(99)00509-0.

Authors

R N Atkinson¹, S B King

Affiliation

¹ Department of Chemistry, Wake Forest University Winston-Salem, NC 27109, USA.

PMID: 10571154
DOI: 10.1016/s0960-894x(99)00509-0

Abstract

Guanidine-substituted imidazoles were prepared and evaluated as inhibitors of the three isoforms of nitric oxide synthase. These results identify a new 2-substituted imidazole as an isoform selective inhibitor and illustrate the possible importance of the L-arginine side chain in selective isoform recognition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Guanidine / chemistry*
Imidazoles / chemistry
Imidazoles / pharmacology*
Magnetic Resonance Spectroscopy
Nitric Oxide Synthase / antagonists & inhibitors*
Spectrometry, Mass, Fast Atom Bombardment

Substances

Enzyme Inhibitors
Imidazoles
Nitric Oxide Synthase
Guanidine